Chemotherapy Role of Nelarabine in T-Cell Lymphoma

Nelarabine plays a key role in chemotherapy protocols for treating T-cell lymphoblastic lymphoma (T-LBL), a rare and aggressive form of non-Hodgkin lymphoma. As a purine nucleoside analogue, Nelarabine works by disrupting DNA synthesis in abnormal T-cells, helping slow their rapid growth.

Typically used in patients with relapsed or refractory T-LBL, Nelarabine is often part of a multi-drug regimen. Its inclusion depends on patient response to earlier treatments, age, and overall health. Due to its potential neurotoxic effects, close monitoring is essential during therapy.

By targeting T-cell-specific pathways, Nelarabine improves treatment outcomes in difficult cases. Research continues to explore its role in standalone and combination chemotherapy strategies.