Avastin® (Bevacizumab) Biosimilars, By Roots Analysis

In 2020, revenues from the sales of Avastin®, Roche’s anti-VEGFA antibody based therapeutic, were observed to have declined by 25% due to competition from biosimilars, in the United States, Europe, Japan, and other nations where it is approved

Roots Analysis has announced the addition of the “Avastin® (Bevacizumab) Biosimilars – Pipeline Review and Partnerships” report to its list of offerings.

Biosimilars of bevacizumab are currently approved / being developed to treat colorectal cancer, non-squamous non-small cell lung cancer, glioblastoma, renal cell carcinoma, and cervical cancer. Experts believe that a strong biosimilar portfolio is equivalent to a blockbuster product, at least for companies with marketing power and reach; as a result, several big pharma players are actively involved in this upcoming category of healthcare products.

Key Report Highlights

In 2020, Roche lost more than USD 6 billion in international revenues due to biosimilar competition
This substantial erosion in sales is evidence of the market capturing potential of biosimilars, despite the numerous barriers that exist both in the United States and internationally, which prevent such drugs from challenging their much higher-priced originator products

Over 40 companies are currently involved in the development of Avastin® biosimilars
It is worth highlighting that there are 45+ products, representing 9 unique biosimilars of bevacizumab, which have either been approved / launched in various regions of the world. Some of the latest additions to the growing list of bevacizumab biosimilar approvals in the EU, include ALYMSYS® (2021) and AYBINTIO® (2020).